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| 中文名 | Cladribine | ||
| 英文名 | Cladribine | ||
| CAS号 | 4291-63-8 | MDL | |
| 分子式 | C10H12ClN5O3 | 分子量 | 285.69 |
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规格及纯度：European Pharmacopoeia (EP) Reference Standard
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Sigma-Aldrich原装
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Macklin原装
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| 产品名称 | Cladribine |
| 英文名 | Cladribine |
| CAS号 | 4291-63-8 |
| MDL号 | |
| Smile Code | |
| 分子式 | C10H12ClN5O3 |
| 分子量 | 285.69 |
| 沸点 | 210-220 °C |
| 储存条件 | 储存温度2-8°C |
| 象形图 | |
| 警示词 | |
| 危险声明 | |
| 警告声明 | [X] |
| Smile Code |
用途:It is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s).
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).
